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IN VITRO STUDY OF SILANOL

Vitamin C – NEW STABILITY FRONTIER

PIERRE-ANTOINE DEGLESNE
RODRIGO ARROYO
JAVIER FIDALGO LÓPEZ
LILIAN SEPÚLVEDA
EVGENIYA RANNEVA
PHILIPPE DEPREZ

Silanol stabilizes and maintains key components of extracellular matrix. Organic silicon-based formulations used in aesthetic treatments differ substantially between the marked medical devices that may result in unpredictable effect in the skin. Organic silicium, methylsilanol mannuronate, present in a dermal implant RRS® Silisorg (200 mg/mL, CE Class III medical device) and associated to an antioxidant resveratrol has been shown on in vitro skin model to increase fibroblast viability and expression of  collagen type I, elastin and hyaluronan synthase type 2 genes with latter responsible for the production of high-molecular weight hyaluronic acid…

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